FASTtrack Pharmaceutics - Dosage Form and Design


Cover





Contents
[php]1. Pharmaceutical solutions for oral
administration . . . . . . . . . . . . . . . . . . . . 1
General description 1
Advantages and disadvantages of
pharmaceutical solutions for oral
administration 2
Drug solubility 2
Excipients used in pharmaceutical
solutions for oral administration 6
Types of pharmaceutical solutions 15
Multiple choice questions 21
2. Pharmaceutical disperse systems 1:
suspensions – general principles and
the formulation of suspensions for oral
administration . . . . . . . . . . . . . . . . . . . 25
General description 25
Advantages and disadvantages of
pharmaceutical suspensions 26
The physical stability of pharmaceutical
suspensions 27
Formulation considerations for orally
administered suspension formulations 33
Excipients used in the formulation of
suspensions for oral administration 35
Multiple choice questions 42
3. Pharmaceutical disperse systems 2:
emulsions and creams . . . . . . . . . . . . 45
General description 45
Advantages and disadvantages of
pharmaceutical emulsions 46
Emulsion instability and theories of
emulsification 47
Formulation of pharmaceutical emulsions 55
Excipients used in pharmaceutical
emulsions 65
Manufacture of emulsions 70
Multiple choice questions 70
4. Pharmaceutical disperse systems 3:
ointments, pastes, lotions, gels and
related formulations. . . . . . . . . . . . . . . 75
Introduction 75
Advantages and disadvantages of
pharmaceutical ointments, pastes,
lotions, liniments, collodions and gels 76
Pharmaceutical ointments and pastes 77
Pharmaceutical lotions, liniments,
collodions and paints 86
Pharmaceutical gels 88
Multiple choice questions 99
5. Parenteral formulations . . . . . . . . . . . 103
General description 103
Routes of parenteral administration 103
Advantages and disadvantages of
parenteral formulations 106
Formulation considerations for
parenteral formulations 108
Surface-active agents 115
Multiple choice questions 131
6. Ocular, nasal and otic dosage forms. . 135
Introduction 135
Advantages and disadvantages of
ocular dosage forms 136
Administration of therapeutic agents
to the eye 137
Nasal formulations 150
Otic formulations 152
Multiple choice questions 154
7. Vaginal and rectal dosage forms . . . . 157
Introduction 157
Rectal dosage forms 157
Vaginal dosage forms 174
Multiple choice questions 177
8. Respiratory dosage forms . . . . . . . . . 181
Introduction 181
Advantages and disadvantages of
respiratory drug delivery 181
Physiology of the respiratory tract 182
Factors affecting the deposition of
particles/droplets within the respiratory
tract 184
Mechanisms of particle deposition
within the respiratory tract 185
Formulation of respiratory dosage forms 187
Multiple choice questions 199
9. Solid-dosage forms 1: tablets . . . . . . 203
Introduction 203
Advantages and disadvantages of
tablets as dosage forms 209
Manufacture of tablets 210
Tablet defects 243
Postprocessing effects on tablet
properties 243
Coating of tablets 244
Multiple choice questions 251
10. Solid-dosage forms 2: capsules . . . . 255
Introduction 255
Advantages and disadvantages of
capsule formulations 256
Materials and manufacture of
capsules 256
Formulation considerations for hard
gelatin capsules 260
Soft gelatin capsules 266
Multiple choice questions 270
Multiple choice answers 273
Index 276



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