cyanide toxicity
it binds to Fe of cytochrome oxidase ....inhibiton of cytochrome oxidase.....cell cant utilize
oxygen .....cell hypoxia
strycnine
antagonize glycine receptor (inhibitory neurao transmitter in ventral horn of spinal cord
so antagonize glycine action.......excessive stimulation of spinal cord ........tonic convulsion
caffeine
antagonize adenosine receptor in cerebral cortex (which is inhibitory neuro transmitter in cerebral cortex ).... excessive stimulation of cerebral cortex.... clonic convulsion
nicotine
....... stimulation of nicotinic receptor in motor end plate of skeletal muscle
tremors and twitches
ptz
inhibit GABA in brain sem ......excessive stimulation of brain stem ...clonic convulsion
opc
inhibit AChE...... acumulation of ACh in
skeletal muscle....tremors
muscarinic receptor...salivation