Practical Pharmaceutics ......... 3rd section ....
بسم الله الرحمن الرحيم
السلام عليكم ورحمه الله وبركاته
ان شاء الله ده عملى الصيدلانيات ............ السكشن الثالث
ان شاء الله هنشتغل 2 medicated prescriptions على ال effervescent granules ..........
1st prescription ......... preparation of Anti-anemic effervescent granules
طريقه السؤال فى الامتحان كالتالى:
send 15 gm eff. gr. containing 5% Ferric ammonium citrate
N.B. ال Ferric ammonium citrate ده هو ال Anti-anemic agent وبيكون
(colored : brown color)
calculation
نفس طريقه ال calculation لاى prescription :
Required amount = 15 gm
Excess amount = 15 * (25/100) = 3.75 gm
so ... Total amount = 15 + 3.75 = 18.75 gm
Drug amount = 18.75 * (5/100) = 0.94 gm
so ..... real amount of the base =18.75 - 0.94 = 17.8 gm
Amount of each ingredient
Amount of NaHCO3 = 17.8 * (510/1000 ) = 9.08 gm
Amount of citric acid = 17.8 * (180/1000) = 3.2 gm
Amount of tartaric acid = 17.8 * (270/1000) = 4.81 gm
Amount of sucrose = 17.8 * (150/1000) = 2.67 gm
Method of preparation
نفس ال Method اللى اشتغلنا بيها السكاشن اللى فاتت لكن الفكره الجديده هنا :
ان ال Drug >>>>> Brown color وبالتالى مش هينفع نعمله grinding فى ال
porcelain mortar علشان ميحصلش staining لل Brown color فى ال
porcelain mortar
علشان كده هنعمل grinding ل drug فى Glass mortar
وبالتالى فى ال prescription دى هيكون عندنا 2 mortars :
porcelain mortar ............ ل 4 powders الثابتين فى اى prescription
Glass mortar ................ ل Drug
1. grinding the colored Drug in glass mortar
2. grinding 4 powders separately in porcelain mortar
then mix the 4 powders geometrically
3. Add (2) to (1) ....... Not the reverse
, Then make geometric mixing ........ till give homogenous color
ملحوظه : بعد ما نعمل ال grinding هننقل ال 4 powders على ال Drug فى ال
Glass mortar "وليس العكس" ......... ونعمل geometric mixing كويس جدا
لحد ما يديناhomogenous color (مهم)
ده بالنسبه للخطوه الزياده فى ال prescription وبعد كده نعمل ال general steps :
4.wetting by 95% ethanol until doughy mass
5.sieving
6.drying
7.evaluation
N.B. فى خطوه ال evaluation المره دى هنزود نقطه كمان على ال 4 نقاط اللى
بنحسبهم كل مره لان ال Drug ...... colored وبالتالى هنشوف :
Homogeneity of the color
ودى بنزودها فى حاله لو كان ال Drug ...... colored
1.onset of effervescence in seconds
وده غالبا بيكون immediately وده دليل ان ال eff. gr. كويسه
2. duration of effervescence in seconds
3. volume of eff
4.clarity of the solution
وده له حالتين : 1.لو كان ال drug ....... soluble in water تبقى clear
2.لكن لو كان drug ....... insoluble in water تبقى turbid
5."Homogeneity of the color"
ده اول prescription ان شاء الله
2nd prescription .......... preparation of Anti-inflammatory eff. gr
طريقه السؤال فى الامتحان كالتالى :
send 15 gm eff. gr. containing 10% of Anti-inflammatory drug
calculation
بنفس الطريقه :
Required amount = 15 gm
Excess amount = 15 * (25/100) = 3.75 gm
so ... Total amount = 15 + 3.75 = 18.75 gm
Drug amount = 18.75 * (10/100) = 1.875 gm
so ..... real amount of the base = 18.75 - 1.875 = 16.875 gm
Amount of each ingredient
Amount of NaHCO3 = 16.875 * (510/1000 ) = 8.61 gm
Amount of citric acid = 16.875 * (180/1000) = 3.04 gm
Amount of tartaric acid = 16.875 * (270/1000) = 4.56 gm
Amount of sucrose = 16.875 * (150/1000) = 2.53 gm
Method of preparation
هنشتغل ال general steps ومفيش اى خطوات زياده لان ال Drug هنا
solid powder وكمان مش colored :
1. grinding separately in porcelain mortar
( وال drug عباره عن solid powder وبالتالى هنطحنه عادى مفيش مشكله )
2.geometric mixing
3. wetting by 95% ethanol until doughy mass
4. sieving
5. drying
6.evaluation
بنفس الطريقه اللى اشتغلنا بيها قبل كده .......
ده ال 2nd prescription ان شاء الله
N.B. ان شاء الله مننساش :
Important precautions for preparation of any prescription
1. لازم كل الادوات تكون dry
2. نبعد عن ال W.B واحنا شغالين بنجهز ال pw
3. well grinding of powders especially citric acid , sucrose (crystalline
4.adjustment amount of alcohol
5. color must be homogeneously distributed
الأدوات المطلوبه ان شاء الله :
- علبه موازين
- swatch glass
- spatula
- measuring cylinder (10ml &100 ml
-beaker
- كبريت
- dropper
- فوطه
- container
- paper
- مذكره العملى
الدكتوره قالت : ان الشرح ان شاء الله المفروض يكون مكتوب معانا فى السكشن ..........
ده ال 2 prescriptions للسكشن الثالث ان شاء الله .........
وده اخر سكشن هنشتغل فيه ال effervescent granules ان شاء الله .......
وبكده يبقى اخدنا 6 prescriptions على ال effervescent granules...........ومطلوب فى اى prescription :
1.Preparation of Non-medicated effervescent granules
2. Preparation of Uricosuric effervescent granules
3. preparation of antispasmodic effervescent granules
4. preparation of Anti-rheumatic effervescent granules
5. preparation of Anti-anemic effervescent granules
6.preparation of Anti-inflammatory effervescent granules
1. Calculations
2. Method of preparation
3. Evaluation
وفى كل ال prescriptions بتكون تقريبا نفس الطريقه باستثناء اختلافات بسيطه .........
آسف على الاطاله ........ وآسف على اى خطأ او سهو .......
اللهم وفقنا جميعا يارب لما تحبه وترضاه .........
.gif "Fop (29)")
.gif "Fop (27)")
المشاركة الأصلية كتبت بواسطة khokha
.gif "Fop (28)")
